Aldosterone
Aldosterone is a hormone found in the human body. It is secreted by the zona glomerulosa of the adrenal cortex in the adrenal gland. Aldosterone is classified as a mineralocorticoid.
Secretion and Production
Aldosterone is secreted by the zona glomerulosa of the adrenal cortex in the adrenal gland. It is synthesized from cholesterol by aldosterone synthase. Its production and secretion is stimulated by an increase of either angiotensin II or potassium in the blood.
The primary effect of aldosterone is the regulation of sodium metabolism. It is responsible for control of the Na+K+ pump. It increases the permeability of the kidney tubule’s apical membrane to potassium and sodium, therefore activating the Na+K+ pump. This stimulates (ATP) production, reabsorbing sodium ions and water into the blood and excreting potassium into the urine.
Pharmacological Uses
There are two common uses of synthetic aldosterone:
Hypoglycemia
Synthetic aldosterone is commonly used as a treatment for hypoglycemia caused by adrenal fatigue. Because aldosterone promotes kidney function, it is necessary in control of blood-sugar levels. Synthetic aldosterone can work to promote normal kidney function and blood-sugar levels in cases of hypoglycemia caused by adrenal fatigue.
Addison’s Disease
Addison’s disease is caused by an insufficient production and secretion of cortisol and, in some cases, aldosterone. Patients with Addison’s disease with an aldosterone deficiency are often treated with synthetic aldosterone. This can help to lessen their symptoms and discomforts.