Anti-Müllerian Hormone
The anti-müllerian hormone (AMH) is a hormone found in a male human embryo. It is secreted by Sertoli cells of the testes. AMH is classified as a peptide hormone.
Secretion and Production
AMH is produced in and secreted from the Sertoli cells of the testes during the development of a male fetus. Müllerian ducts are what form the genital passages in female embryos. AMH is secreted by both testicles in a male embryo, therefore preventing the formation of female genitalia. This is the main effect of AMH.
AMH is absent in females until puberty, when it is secreted from the granulose calls of the ovary, inhibiting oocyte meiosis. AMH production and secretion continues in males until puberty and declines thereafter.
Pharmacological Uses
Though AMH has been synthesized, it is not currently administered as a supplement. However, researchers are studying it use in treatment of endometriosis, adenomyosis, and uterine cancer.