Luteinizing Hormone
Luteinizing hormone (LH), often called interstitial cell stimulating hormone (ICSH) in males, is a hormone found in the human body. It is secreted by the gonadotropes in the anterior lobe of the pituitary gland. LH is classified as a peptide hormone.
Secretion and Production
LH is secreted by the gonadotropes in the anterior lobe of the pituitary gland. It has different roles in the male and female, though it’s important to the reproductive process in both. In females, LH prepares the uterus for implantation of a fertilized egg. It stimulates the ovulation process, and it also stimulates the secretion of progesterone by the corpus luteum. In males, ISCH promotes the secretion of testosterone, which is the most important male androgen.
Pharmacological Uses
Though there is no form of synthetic LH, there is a form of synthetic luteinizing hormone releasing hormone (LH-RH) that works to promote secretion of both LH and FSH. Synthetic LH-RH is generally used as a fertility drug in patients with hypothalamic hypogonadism — a disorder of the hypothalamic gonadotropin-releasing hormone (GnRH) pulse generator that results in deficient or dysrhythmic GnRH release. GnRH causes the secretion of both LH and FSH, so, in cases of hypothalamic hypogonadism, LH_RH can help to increase the fertility of both males and females.